Calcium signalling: Sphingosine kinase versus phospholipase C?
نویسندگان
چکیده
منابع مشابه
Calcium signalling: Sphingosine kinase versus phospholipase C?
A recent study shows that sphingosine kinase and its lipid product have an essential signalling function; they act in the mobilization of calcium ions in antigen-stimulated mast cells. This finding may have relevance to signalling in other cells of the immune system.
متن کاملCalcium Signalling: The Ups and Downs of Protein Kinase C
Oscillations in intracellular calcium levels control a plethora of physiological processes, but how they are decoded by a cell remains unclear. In a recent study, advances in FRET technology have been used to describe how calcium oscillations are decoded through phase-locked oscillations in substrate phosphorylation catalysed by protein kinase C.
متن کاملRole of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability.
We previously demonstrated that vascular endothelial growth factor (VEGF)-elicited increase in the permeability of coronary venules was blocked by the nitric oxide (NO) synthase inhibitor NG-monomethyl-L-arginine (L-NMMA). The aim of this study was to delineate in more detail the signaling pathways upstream from NO production in VEGF-induced venular hyperpermeability. The apparent permeability ...
متن کاملSphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts.
Sphingosine (Sph) has been implicated as a modulator of membrane signal transduction systems and as a regulatory element of cardiac and skeletal muscle physiology, but little information is presently available on its precise mechanism of action. Recent studies have shown that sphingosine 1-phosphate (S1P), generated by the action of sphingosine kinase (SphK) on Sph, also possesses biological ac...
متن کاملSphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors.
Formation of inositol 1,4,5-trisphosphate (IP3) by phospholipase C (PLC) with subsequent release of Ca2+ from intracellular stores, is one of the major Ca2+ signalling pathways triggered by G-protein-coupled receptors (GPCRs). However, in a large number of cellular systems, Ca2+ mobilization by GPCRs apparently occurs independently of the PLC-IP3 pathway, mediated by an as yet unknown mechanism...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 1996
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(02)00598-5